Regeneration of sciatic nerve crush injury by a hydroxyapatite nanoparticle-containing collagen type I hydrogel
نویسندگان
چکیده
منابع مشابه
The effect of collagen-binding NGF-beta on the promotion of sciatic nerve regeneration in a rat sciatic nerve crush injury model.
Nerve growth factor plays a critical role in peripheral nerve regeneration. However, the lack of efficient NGF delivery approach limits its clinical application. It has demonstrated in our previous work that the native human NGF-beta (NAT-NGF) fused with a collagen-binding domain (CBD) could bind to collagen specifically. Since collagen is the major component of nerve extracellular matrix, we s...
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BACKGROUND Zofenopril is an antioxidant agent which has been shown to have beneficial effects in hypertension and heart failure. The aim of this study was to test the effects of Zofenopril on nerve regeneration and scarring in a rat model of peripheral nerve crush injury. METHODS Twenty-one adult Sprague-Dawley rats underwent a surgical procedure involving right sciatic nerve crush injury. 15...
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لطفاً به چکیده انگلیسی مراجعه شود.
متن کاملLocalization of Epidermal-Type Fatty Acid Binding Protein (E-FABP) in Degeneration and Regeneration of Sciatic Nerve after Crush Injury in Mouse
Purpose:The regeneration of axon and myelin sheet after crush injury of peripheral nerves involves interaction of several types of cells, including Schwann cells, monocyte, macrophage and fibroblast. Among them, haematogenous macrophages invading into the peripheral nervous systein play a major role in myelin uptake during Wallerian degeneration. Materials and Methods: In this study 35 C57/BL6 ...
متن کاملRat sciatic nerve regeneration through type I collagen-derivedartificial tubular implants
Objective: To investigate the efficacy of a type I collagen-derived artificial tubular implant on sciatic nerve regeneration. Materials and Methods: Sprague-Dawley rat sciatic nerve injury model was built by cutting a 5.0 mm defect on the sciatic nerve of the right thigh. Rats with sciatic nerve injury were treated with type I collagen-derived artificial tubular implants (Group A), autologous c...
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ژورنال
عنوان ژورنال: The Journal of Physiological Sciences
سال: 2017
ISSN: 1880-6546,1880-6562
DOI: 10.1007/s12576-017-0564-6